Mouse clicks off by an inch to left

After not playing the game for a couple of weeks I come back and now I am unable to play the game as the mouse clicks are off to the left by an inch. I have nothing playing in the background and I tried to use the fix in Nvidia settings to set the 3D DSR Factor settings to off but the lowest it goes is 1.2%.

Help!

Closing this thread as we got it resolved over here.