I play with a combination of keyboard and clicking. Generally my main rotation is 1-5, and my interrupt is usually on 6. Everything else pretty much gets clicked.
It drives my gf insane. It’s what works for me though!
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I seem to be the only one who does this, but my 3 side button on my mouse are bound to Ctrl shift alt. This way I can bind 4 spell per keys.
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thats pretty smart.
Honestly thats the best. Trying to swap from something that works and has worked for you just isnt worth it 
my keyboard binds are limited to R and F, and Z for mount
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A mouse binding I always thought felt nice is binding death grip to scroll down. It feels proper.
but then how do you zoom out without activating it
On the Druid I use the side mouse buttons plus CTRL and Shift to bind my various funny animal forms.
Top button is movement moves like sprint or burning rush, bottom button is utility moves.
Would’ve been interrupts but that’s my Z key.
Geebsus… you use two hands with that?
back button i use for my interrupt spell. forward is for mount.
what do you use to zoom in and out then?
Stealth and shadowstep
Some thing that’s an instant cast or pending the class a Dot or Hot.
I focus healingg and/or defensive on my mouse keys too.
Potion, health stones, mirror image, ice block and shield are all mouse keybinds.
The only spell that isn’t is rune of power.
Thumb button back is push-to-talk. Thumb button forward is various things depending on the class.