@ Deram
I found when I launch the Launcher, then modify permissions on Hotfix.log the settings stayed until the next time I launched the Launcher.
Also, this problem seems similar to a problem people were having last year in October after a major update. Hotfix.log & DBCache.bin would grow each time between realm swaps and each time the profession menus were opened. The file would grow so large that the game would eventually hang when these actions were done.
https://us.forums.blizzard.com/en/wow/t/long-load-times-character-select/16837