After the latest update (11.0.5.57212), my actions bars - Action Bar 6, Possess Bar, and Stance Bar specifically - reposition to the top-left after every /reload and when I relog. The only temporary solution I have is to switch between a default layout back to my custom-made layout.
Your not the only one, this is huge on EU forums, after this weeks patch. A quarter of my guild has same issue. I have etc. Deleted addons, deleted folders, renamed stuff, re-installed nothing working edit isnt saving it right have to swap betweet ui every time from scratch this is an anoying bug and blizz hasnt said anything.