If you played with every mutator on at once?

What would probably contribute the most to getting you killed as soon as possible? I was thinking about asking my friend to play with every mutator on at once with the goal of simply lasting 5 minutes without dieing. If I try this, what do I have to worry about the most?

Not sure. I guess there could be variations.

The meta is your computer won’t be able to handle them

speed freaks, alien incubation, transmutation. a mule dies, broodlings will get to your base before void rifts even spawn.

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Gonna give it a try. Ill let you both know how it goes.