‘‘Easily’’ By landing a slip skill shot on a slim hit box hit 2 projectile shots and sacrifice all of her abilities, and thats assuming they cant kill you or run away first. Take Sombra as a prime example she can translocate away after the first shot hits and be on her merry way and now Anas sleep is on CD and she cant combo you again.
Aaaand Sombra can kill 90% of the roster with half a clip of her gun without headshots. If sleep doesnt require follow up hack requires even less. And even then Anas teammates can wake up the enemy before she can do anything to them completely negating her skill shot.
And even then, hacking an ulting enemy doesnt require follow up to get use out of it.