I just lost a ladder match due to a bug, I played two plague weapons (found with other cards - the Primus and the discover a weapon spell). My opponent had 3 plagues of a kind and another double one in the deck, when she played Reno it activated its battlecry and wiped my board. I didn’t play around that because I chose to pick the plague weapons ONLY TO DENY Reno!
multiple things can do that , Steamcleaner , drawing plagues if you dont use Heyla , using Sir Finley to directly move plagues to hand , deck changing cards ( there are some ) , etc. etc.