not sure how much blizz actually cares about Mac nowadays but I went from being able to play on high settings 2 years ago, to having to put all settings on low a year ago (to avoid crashing while tabbing), and now on sequoia the game crashes the entire computer when its loading.
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I can confirm this is happening after OSX 15.0 update.
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Same here 
And it’s not just the game crashing, the entire OS crashes as well.
It’s quite consistent, it’s bound to crash within 5 minutes of starting the game.