Card interaction,

While Playing the Rastakan’s Rumble the hunter secret that makes your minion attack itself removed my shrine from the battlefield instead of just killing it and making it flip over. I was playing the Priest shrine that damages when you heal, and was playing against the secret hunter shrine guy at the time. I had my shrine at a 9/9 and attacked with it, it then damaged itself and died. Instead of flipping over like it usually does it was removed from the board.

Known issue:

  • Rumble Run: Shrine can be destroyed from activating Freezing Trap.

Are you sure it was due to Misdirection?
As shown in the post Norit links to, there is a known issue with Freezing Trap causing this. But I have so far not seen any reports of the same problem happening with any other secrets.

If this is indeed a new issue, then you can help Blizzard find the root cause by posting additional information, preferably in the form of an hsreplay.net link, or of screenshots taken when this happened.