I started a new run in Underground and selected the Eliza Goreblade legendary bucket to start, which gave me one of each rune (Deathgrowl was in the bucket).
The first set of draft picks offered me Marrow Manipulator, a double Frost card. However, it wouldn’t let me select it, probably because I couldn’t meet the rune requirement. It effectively only let me select from 2 cards instead of 3.
Cards that don’t meet the deck’s rune requirements should be excluded from draft options.