Here are some suggestions:
- Set to Windowed Fullscreen.
- Vertical Sync on.
- Resolution Percentage - 100%
- Frame Generation off (40xx Series only)
- Start with a cap of 60FPS. (we can increase this in small amounts later)
- Disable DLSS.
- Disable Reflex.
- Disable Peripheral Lighting.
- Use defaults for the quality settings. If not sure, reset to defaults then set suggestions above. We can then make small changes from here, once we have it stable.
Note, these are to try to get you to a starting point where it should work. Try setting to the above, then restarting the game and see if it plays any better. If so play it for a while with these settings. see if its any better for a long session.
Then, you can start with small changes. FPS I know everyone wants higher, but don’t exceed your monitor refresh rate. No point in it. And with how D4 plays, you honestly won’t need a high FPS anyway and keeping it lower does ease the load on your GPU.
From there, again, make singular small changes.
Good luck.