Thanks for the fix man, back up to 140+ fps @ 1440p again with no lag/fps stutters thus far as opposed to the moments of well under 30 fps prior.
As per your directions, the settings were not available for me as Diablo 3 specific using NVIDIA Control Panel version 8.1.940.0, they were however found at: (3D Settings -> Manage 3D Settings -> Global Settings). For those NVIDIA users who were looking word for word for the options, a few of them are listed a little differently.
- Texture filtering - Negative LOD bias
- Texture filtering - Trilinear optimization
- Virtual Reality pre-rendered frames
- Prefered refresh rate (monitor model #) -> Highest available