When clicking spell spell on main action bar, it makes the push down animation but never casts. Help

So I have a few buffs that i cant be bothered to keybind, but this problem is driving me up the wall. It also doesnt generate a tool tip. Its only the main action bar, i have a seperat bar and it works fine. Anyone have an idea what this problem is?

It seems to be a bug since they enabled cross-faction groups. Out of combat you’ll often get the hand when casting a buff (unless targeting someone) and will need to click on someone to finish the cast, regardless of your auto cast options. In-combat they seem to fire automatically.