The information provided from the other posts are correct. Try a full UI reset to see if that gets things working again.
If that doesn’t work that means it’s a overlay. Some of the most common ones are:
Nvidia overly (Shadowplay)
Discord overly
Overwolf overly
Nahamic sound overlay
Xbox Game Bar
If you continue to have issues you can submit a Support Ticket so the Customer Support team can take a look into the computer and pinpoint what’s causing the trouble.