Unable to add click keybindings for characters with pre-existing keybinds after 11.0 update

[Meattotem-frostmane]

This seems to be related to this issue:

Click casting refuses to bind decurse spells for any class

Maybe another addon is set to autocast it when a debuff is on the target with some other key combination. You mentioned reinstalling, but did you go scorched earth? I checked across the forum and reddit and couldn’t find another report of this, so it’s likely something specific to your files/game setup.