As of 10.1 launch the mini-maps invisible boundaries are extending far beyond where they should to the point it takes up the whole screen and doesn’t allow you to interact with anything behind invisible boundaries, no mouse-over interactions, nothing. I have managed to make the boundaries smaller but 20% of my screen is not able to be interacted with.
EDIT** Blocky has pointed out it’s an addon called MapCoords and disabling it fixes the issue.