Question - Runes' SKILL and miss-rate specifically Envenom

I pose the question, does the Runes Skill being only 75/75 have any effect on the miss-rate with what should be sufficient hit rating?
I have run up to 20% +hit and still have chain misses on envenom that are not reasonably explainable.
The mobs/bosses not immune (yes those suck), but still somehow we can chain miss on envenom 5 times in a row? and it has happened multiple times during a long enough fight.

Is it possible that changing runes in our skill window to 300/300 would have some kind of beneficial effect?

Apologies if anyone has already asked~

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What kind of hit exactly?

Just plain “hit”?
Or “hit with spells”?
Or “hit with all spells and attacks”?

Does Envenom count as a melee attack or a spell?

Even if you consider that 5% of it from our talents is probably melee only, we should have 6 from the ring if its considered a nature spell, so when I was 20% melee hit, it should have been 21% spell hit, which is over still well over spell hit cap?