It’s important to mention how much desk space you have, because that will change some of the recommendations.
In terms of the stuff you mentioned(based on what I’ve seen) -
Bose Companion 2 - They seem ok, a little hollow shouty sounding in the mid-range however, probably from the enclosure. If you saw these, you probably also saw the more expensive 20s, however they aren’t really worth it compared to the other options in their price range, as the 20s tend to have quite a lot of bass(almost like you have a mini subwoofer) with some slight distortion, and is a sort of scooped sound, which sounds kind of dry and empty.
G560 - They don’t seem to sound very good, even Logitech’s other offerings would likely be better
Z333 - Can’t comment on this one, it’s probably average, but it’s not the 2.1 I’d choose from Logitech(the one I’d buy is not for sale right now anyway for some reason)
Z313 - Don’t buy this one, it’s one of the worst 2.1s that Logitech sells.
Z200 - Very basic, high bass rolloff with muddiness, but overall it has a passable tone, especially for the price. If you only had maybe $20 to spend, I’d buy it, but not if your budget is much higher.
Creative Pebbles - Don’t do anything particularly well from what I’ve seen compared to the Z200 at the same price. Creative also has other options that are much better for their price points(such as the T40 and T10).
If you need a small 2.0 speaker and like you say - budget is no issue, you can get either the iLoud Micro Monitors or the Vanatoo Transparent Zero depending on your sound tastes. If these two are out of what you can spend, I can suggest cheaper options. You may prefer the Vanatoos, and those are what I would get if I had no budget and needed a smaller speaker. These two wipe the floor against any other compact 2.0 speaker, but compact speakers usually are limited in their ability to an extent. Compact speakers tend to lack bass frequency extension, and tend to have a big bass boost in the upper bass frequencies making things sound muffled, exaggerated by the room, the two speakers I linked above are one of the few that don’t have a big hump(to cover up their lack of extension) and have decent extension.
If you can fit a bigger speaker, the Edifier R1700BT would be a decent choice. There are better choices, but I’d consider the other options too large for a desk setup, and may not suit vocal content.
I’m not too familiar with what 2.1 sets are decent. So I cannot make a good recommendation in that regard.
If you want a speaker with a specific feature(volume knob on front) that’s also worth mentioning.
If you just want clear dialogue for YouTube/Netflix and don’t mind your house not shaking from explosions, you may want to skip a 2.1 setup, because a number of 2.1 computer speakers have subs that are poorly integrated, which would reduce overall sound clarity. And speaking of 2.1s, Logitech recently introduced a new 2.1 system, but it’s still fairly new and there hasn’t been enough reviews or anything on it to come to a conclusion just yet.
You can purchase all 3 options I mentioned above on Amazon.
I also missed your USB vs 3.5 question originally when writing. If you have terrible on-board audio, you may want to use USB, however USB usually only comes with not so great speakers, and if you have a terrible motherboard it can introduce noise to USB audio devices. I find HP computers tend to have pretty garbage on-board audio. Can’t comment on Dell(since I’ve only had 1, but based on my experience and things I’ve seen online, they’re not very good either), but Lenovo is usually more acceptable on average. But, even if you have bad on-board audio, there are plenty very affordable options out there now for under $20 or so that you can use to hook up your speakers to for passable sound output, I’d have no problem guiding you in that direction as well, because while there’s a lot of cheap junk to sift through, there are a few decent cheap adapters.
If you just want the TLDR -
- Vanatoo Transparent Zero if you have the budget and want something small(I can suggest cheaper options if you want a small speaker, since while you did say no-budget, the options you linked are a lot cheaper lol)
https://www.amazon.com/Vanatoo-Transparent-Powered-Speakers-Black/dp/B01N33WUJ9/
- Alternative option to above for small compact speaker iLoud Micro Monitor
https://www.amazon.com/IK-Multimedia-Monitors-ultra-compact-bluetooth/dp/B01C5RZWCQ/
- Edifier R1700BT if you have the space or don’t want to spend as much
https://www.amazon.com/Edifier-R1700BT-Bluetooth-Bookshelf-Speakers/dp/B016PATXSI/
Note: While I didn’t mention it above, the JBL 305P MKII(you’d have to buy two for a pair) is a decent choice if you have the space, but they do come with a bit of standby background hiss if that doesn’t phase you, then they may be the better choice in this larger category.