TL;DR: Interact Key disables Auto Self Cast when interactable objects are nearby.
I’ve been enjoying the new Interact Key that lets you interact with objects using a keybinding, but I have noticed a pretty big issue that this causes: When there is an interactable object nearby and you try to cast an ability on yourself without a target (with auto self cast enabled) you instead get the glowing cursor indicating that you need to click on a target for the spell. This also seems to interfere with @mouseover macros, though I haven’t done enough testing to figure out exactly how.