Hi in short I have macro for mouseover which works for one combination of spells on frames, on different spell combination it doesnt
MACRO A
#showtooltip
/cast [@mouseover,nodead,help] Chain Heal; Flame Shock
It works when I hover over the player , it works on party frame , healbot frame
MACRO B
#showtooltip
/cast [@mouseover,nodead,help] Healing Wave; Chain Lightning
A works in every situation . B does NOT work on party frames / raid frames / healbot frames, but does work when I directly hover over any player.
Do you have any idea what could be wrong ??
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If you’ve got macro B bound to a mouse button, that’s your likely problem. Frames “eat” mouse clicks, so mouseover macros don’t work with them. If that’s the case, you’ll either need to pick a new keybind or use an addon like Clique.
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I’ve literally never had this problem before, but I just came back to the game after a break since the end of MoP and suddenly there are only specific spells not casting on my unit frames but work perfectly fine hovering over units in the gamefield. I’m literally doing exactly what I always have but spells like detox and chi cocoon are no longer casting when mousing over the frames (on thumb buttons) while chi wave (and all my other heals) work fine, while being bound to the mouse wheel.
I used to use a naga when I first started in cata (and those are re… you know what I’m just going to bind my thumb buttons to the number row like that mouse was to avoid the problem if it’s literally just that extra mouse buttons randomly don’t work with unit frames (something blizzard should really address since the game is like 20 years old)).
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Remapping those extra mouse buttons to keyboards keys should fix your problem. I haven’t played with it, but the recent patch added click casting to the default UI. If you go into keybindings, there’s a button “Click Casting” in the lower left corner above the Reset Defaults button. So, that’s another thing you can play with to see if it solves your problem.
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Should check back in here, it totally solved it, just mapped mouse 4 & 5 to keyboard = & - and made a new profile for wow.
I just forgot that the naga used the number row as default thumb bindings and that’s why I never had an issue in the past.
I honestly never even knew it was an issue until now.
Otherwise I assume you would have to use an addon like clique to circumvent the shortcoming of the standard game functionality.
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I never even realized that this was a thing until I read your post lol
This is a necro, but in case anyone has the same problem and finds this through Google like I did — going into Click Casting and adding the macros, and mirroring the macro’s actual keybind to the prompt worked for me. 
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