Hey there,
I had this issue a ton before and this patch seems to have fixed it for me, although now it’s sadly cropping up for many others.
I wanted to mention that, while troubleshooting, you can replicate this issue pretty easily by dragging your cursor above the center of your screen a distance, hold down right click, then slide the mouse either left or right quickly then release (repeat this quickly to try to get the cursor to reset for testing purposes). In ideal circumstance, the cursor hasn’t reset to the center or slid in the direction of the movement. This should assist you as you try the troubleshooting to quickly test and try something else.
Apparently the most likely cause so far sounds like either a problem addon or other program on your pc messing with WoW that causes the issue, and resetting these things can be a huge pain with how Twitch or other software’s overlays attempt to save your settings.
Hopefully you get it fixed!