Every time I enter/leave an instance all my poisons are removed except for crippling poison as assassin.
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This usually happens when you get into a rated match and apply your poisons while waiting for the countdown. Apply your poisons before you get into the queue, and they’ll stay on after you’re back out. I believe it’s been like this for multiple expansions now, and I think it has something to do with letting you choose your poisons for that specific rated match only.
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This used to happen in timewalking as well but probably still does with most instances you enter.