Here is what I did to make Blizzard’s Click casting similar to Healbot for me. This is obviously what works for me, but it’s a start on the process for others.
Edit Mode
On Party Frame, check box for Use Raid-Style Party Frames
Perhaps set Sort to Role
In HUD Edit Mode
Check all the boxes under Frames and Combat, then put your Player Frame, Party Frame, Pet Frame, and Focus Frame where it's convenient for you.
Options → Gameplay → Interface, under Raid Frames
Check
Display Power Bars (This shows the mana/energy bars. While there is an option for showing healer only, it didn’t appear to work properly in Delves.)
Display Pets
Show Debuffs
Display Only Dispellable Debuffs
Display Health Text → Set to Health Remaining
Debuffs show on the bottom left of the party member’s bar and buffs are on the bottom right. I wished the player bar changed colors like Healbot does, but maybe Blizz will implement that later.
This is where you bind the spells/macros to your mouse buttons
Options → Gameplay → Keybindings → Click Casting
I set the defaults to use Alt-Left and Alt-Right instead of the Left and Right mouse buttons that are set by default, since I never really use Alt
Target Unit Frame (Default) (Just selects whoever you are targeting)
Open Context Menu (Default) (Used to access your Player Frame to change things such as Loot Spec, Leave Party, etc.)
Oddly enough, as a healer, it indicates your cleanses aren’t usable by Click Cast, so I created macros in the General Macros, like the one below, so other characters (of the same class) can use the same macro. The DPS cleanses doesn’t have this issue.
#showtooltip Cleanse
/cast [@mouseover, help, nodead] Cleanse
Of course, if you want to activate trinkets, you will have to macro the spells and use a macro instead or use the Cleanse example with the trinket name if it has to use the trinket on a player.
/use 13 is for the top trinket
/use 14 is for the bottom trinket