So, what I’m trying to do here is make a macro that casts Power Word: Fortitude on a friendly target that I click on when I hold down a side button on my mouse. Is such a thing possible?
I am no macro expert so I’m sure there are better ways to do this but I would maybe do something like:
#showtooltip
/cast [@mouseover] power word: fortitude
And the just bind that hotbar slot to the mouse button you want to use.
#showtooltip
/cast [@target, help, nodead] Power Word: Fortitude
you can bind this macro to one of your mouse buttons (or whichever button you’d like to use, really), but wow doesn’t support any kind of scheme where you can hold down a button for an alternate effect.
That is much much better than what I wrote. 
I guess what I’m looking for is a macro that, when I press a button, it readys the spell to be cast, and when I click on someone, it casts it on them. Make sense?
I don’t think it’s possible to “ready a spell” if I can be nerdy and use DnD terms anyways. I think that might be pushing into the limitations Blizzard put in to stop automation.
I dunno. I’m sure one of the macro experts would be able to verify, but I’ve never heard of it.
The addon Clique can basically do this. WoW doesn’t do any kind of “readying” action, so you’ll have to either manually target or mouse over your target, then cast your spell.
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I dont think Ive seen one that does that. Id be interested in that myself.
@mouseover is probably your best bet.
Keybinding combined with a mouse over macro is what you are looking for