My keybind set up is a little weird, and ultimately you should do what feels smoothest for you, but with that being said my keybinds are something like:
‘A’ & ‘D’ are rebound to strafe left and right, I only turn using right click in the mouse.
‘1’ - ‘6’ I can reach with my fingers so they are kept as action keys, I personally keep chi wave, expel harm, purifying brew, celestial brew, niuzao, and touch of death on those keys in that order.
‘7’ & ‘8’ on the main action bar are rebound to middle mouse click and shift + middle mouse click, and are roll & tigers lust
‘9’ & ‘0’ on main action bar are rebound to ‘Q’ & shift +‘Q’, and are AoE control leg sweep and ring of peace
‘-’ & ‘=’ on main action bar are rebound to ‘E’ & shift + ‘E’ and are spear hand strike and provoke
On my twelve button gaming mouse 1-12 are bound to action bar 2, and shift + 1-12 are bound to action bar 3
‘1’-‘6’ on action bar 2 are my primary offensive abilities, black out kick, keg smash, breath of fire, tiger palm, spinning crane kick, & rushing jade wind in that order
‘7’-‘9’ on action bar 2 are trinkets and offensive cds, trinket 1, weapons of order, trinket 2
‘10’-‘12’ on action bar 2 & on action bar 3 are defensive cooldowns, heals, potions, and health stones
‘1’-‘9’ on action bar 3 are less frequently used abilities like clash & transcendence, some macros, and mount for easy fast mounting
Hope this helps!