I think it would be interesting if Warlock soulstones and Shaman Ankh worked exactly once per character, and apply a permanent debuff after. Would make those spells not entirely useless. Perhaps also do the same with resurrect spell, and would only be allowed to be cast successfully once per character, for both the rezzer, and the rezzie. Would create some spicy moments in hardcore i’d imagine. Also i’d imagine some restrictions where you can’t rez someone if they were not in your party and the timer to rez expired after 1 minute.
But this probably wouldn’t happen and most likely would not be widely accepted by the community.