On my druid (Glorathrin-Farstriders), I attempted to open Domination Guard Seal before I had all 4 keys. I had collected the key from Yiva (the Feeder’s Hand and Key) and from a Helgarde Supply cache.
The seal didn’t open (correctly) BUT it did take both of the keys I had collected and no longer allowed me to collect the other 2 keys (for example from the Harrower’s key ring).
A heads up to anyone else trying to get the Nilganihnaht Control Ring (for the golden hand mount).
Happened to me as well. Is there any help for us from support?
I heard back - they said it was working as intended, but poorly documented.
Evidently, it keeps track of what seals you have already opened, so you don’t have to have all 4 at once. Tried it again today and was able to get the remaining keys and open it.
Lol I finally got it as well, but I had no clue as to what I had missed. When it comes to killing tons of mobs on low drop rate, or trying to find scarce treasure boxes to loot, I got lost & frustrated in what one I was missing. The other 2 are very specific. I spent 3 more days grind killing the mobs & looking for chests to loot because I had no idea which to focus on 
It turned out I needed a treasure box drop, but they are not always up & the key drop is random.
Hello, i am having a terrible day with this chest :C… i looted the adds key and use it on the chest and unlock one of the seals, then i farm the next 3 keys and use this ones on the chest but never release the last seals. At this moment i spent 3h of farming the keys again but no loot for me. i use this script:
/run print(C_QuestLog.IsQuestFlaggedCompleted(62683))
/run print(C_QuestLog.IsQuestFlaggedCompleted(62680))
/run print(C_QuestLog.IsQuestFlaggedCompleted(62682))
/run print(C_QuestLog.IsQuestFlaggedCompleted(62679))
and it tells me that i looted all 4 keys, and when i use it on seal event IDs it tells me that seal 3 is false ( not removed ).
I apretiate if anyone can help me with this issue.
Best Regard