Spoilers:
In the latest Vader Comic issue it is revealed that Darth Sidious created Anakin Skywalker. And here we all thought Darth Plagueis was the one responsible for the manipulation of Midi-Chlorians that created Anakin.
Of course the fact that Plagueis taught Sidious everything he knew means that Sidious had all the knowledge of how to create Life.
The only thing he couldn’t do was cheat death and that was likely due to Plagueis not knowing how he gained access to the World Between Worlds. Sidious of course wanted to learn the secret though was denied 3 times(once by Vader and twice by Ezra)!
Of course Sidious being Anakin’s father leads one to ask: Who was it that Plagueis created? Obviously the answer is Darth Sidious! Furthermore Sidious’s creation must have led to the Force lashing out in some manner that Plagueis noticed or else he wouldn’t have told his son Sidious about the Force’s capacity to lash out!
As for what reaction the Force had to Sidious’s creation we can only guess yet it’s ultimate reaction to Anakin’s creation was to draw Padme to him and make him the Chosen One with the help of his son Luke…
Plagueis must have been more competent than Sidious as he noticed the backlash and dealt with it properly and with violence while Sidious mishandled it by not getting rid of Padme immediately.