I will take a look at this when I have the chance later, but I am on Windows 10 and have a pretty basic mouse so I am not sure if it will apply. I believe other modifiers were working; shift+1 as a keybind for example, and a macro I have that uses the alt modifier both worked.
I checked my system time and language settings and they appear correct.
I also reinstalled the Dragonflight beta and hopped on to see if I had the issue there and I do not. It is only on live retail.