This isn’t the Edit Mode > Items frame. I have that off to the side, so that’s where things appear when I click a mob or something.
I’m talking about the individual loot notifications that start at the bottom middle of your screen - one notification for each thing you loot. While you can dismiss each individual notification with a right-click, this isn’t a great solution.
In Remix, if you fly through a line of multiple bronze orbs, the center of your screen gets slammed with stacks of:
You received
21 Bronze
You received
20 Bronze
etc.
There’s no base Edit Mode setting to get rid of this, and even the addon EditModeExpanded doesn’t seem to have a fix for this.
(I had to install EditModeExpanded just so I could see target of target. I couldn’t see it, even though I had it enabled through the base UI. This made tanking pretty awful.)
I’d rather not deal with a full UI replacement. I just moved away from ElvUI to try and ease the load on my ageing computer.