This was a change I made the very first day I played Overwatch.
I started out (Foolishly) trying to play Tracer. And I kept thinking
“This would be so much easier if Blink was on E.”
So I went into the settings and made it happen.
I put about 6 hours into Tracer before deciding she wasn’t for me. I moved on to Reaper next. Again, I was glad that Wraithform was on E and not LShift. Then I started playing Bastion. Again, glad to have Sentry/ Recon button on E. Then Junkrats mine on E was nice too.
So I’ve been playing that way ever since. The only hero I started getting into where that invert didn’t help though, was Hanzos Storm Arrow going to LShift.
But then Moira’s Fade on E is nice too. D.Va’s boosters on E is nice. Especiailly since the E+Q combo is so much easier than Lshift+Q.
I can’t really think of any other heroes actually, where this change doesn’t feel beneficial.
I swapped Pharah’s E and Lshift, and Zen’s E and Lshift. I came from console though and I was just trying to match controls to buttons, and those two were off.
Go to options, then go to the ‘controls’ tab, then at the top right there should be a box saying “all heroes”, click on that and scroll down to your desired hero and then all changes will be specific to that hero.