First, I want to praise Blizzard for going the extra mile. Most of the side quest dialogues change a lot depending on whether you do them before or after the main story. I am sure of this because I finished all the Fractured Peaks quests during the beta before the main story, and then I did them again on the live version after completing the main story. Even the subtle changes in dialogue are a great effort.
That being said, I noticed that some side quests disappear completely if you don’t do them before advancing the main story. Some NPCs who give quests even die.
So my question is, will my renown for side quests be forever incomplete? For example, even though I have 100% renown in Fractured Peaks, my side quests are 31/35, and I am sure I completed all the quests, including the ones you find from drops.