It’s been a while since I’ve played Diablo 3, years really on the PC. I don’t quite remember what my key binds were. I’m not a fan of the current set up and it’s quite hard on the hand.
What are the best key binds and general set up for making abilities easier to hit on the keyboard? What’s everyone’s current set up?
I rebind 1-4 to QWER. Potions on `~ (to the left of 1). Map is tab. Everything else is the same.
As a LH(left hand) Mouse User(standard mouse config - not swapped) and as someone who has used the Number Pad for their Hotkey/Skill/Hold Pos/Move(shooters) etc assignments for pretty much every game(that allows it) since oh…1996 - It’s likely I am of zero help to you 
Controller for the win…give it a try you really might like it!
Getting a mouse with a 12 button thumb keypad changed my gaming life (logitech g600, razer naga, etc). Highly recommend. I play comfortably and relaxed with mostly 1 hand.
e = force walk
shift = force stop
How can we tell you whats best? It depends on your physiology and set up.
Rest your hands in a comfortable position and then put most used abilities there and expand outward from there leaving least used things furthest away from that initial comfortable position.