How much have you played on console? I had over 3k hours in D3. Skill casting is a big disadvantage on console. I’m assuming you know how the target lock feature works? Being able to pick the location of a cast with a mouse or click on a specific enemy in density is way more efficient than using the console target lock system. I don’t see how you can even dispute this. Any ground AOE effect is going to be wherever you click with MK and wherever you are target locked on console. Same with any precision skill. You don’t have to spend time on PC repositioning until you get a target lock on an elite or boss to prevent your casts all landing on trash mobs or adds. Here are some skills negatively affected in D3 by lack of a cursor.
Leap
Blizzard
Hydra
Teleport
Dashing Strike
Vault
Furious Charge
Blood Rush
Impale
Hungering Arrow
Inner Sanctuary
And anything else that pierces or is an AOE ground effect.