The problem with guardian adds is that they melt.
I would calculate the average difference in guardian killing favors Blood by 18%.
I would also calculate that Blighted spear will clear to a GR140 Guardian 26% faster. This is taking into account that your spear rotations are hitting no less than 10+ mobs.
cold rune is a meme
Shatter is actually good for ultra aoe because it multi dips into your aoe, but it’s useless for boss killing.
Teeth is lazy T16
Blood spear costs life.