I have already contacted the devs. over a year ago about this and because no one ever got back to me like I was told and nothing was ever done I thought I’d start a new thread for it…
I have a fresh Windows 7 install (09-09-19) with almost nothing else installed yet and I am discovering the same issue I had on my other laptop. When selecting Large Cursor in the Diablo III options menu if I select Full screen the pointer disappears from the screen completely. I can still guess and click stuff but have no idea what/where. In Windowed Full-screen mode the large cursor works.
I have gone to the ASUS website and made sure to update all my Video Drivers. This is the same issue I had on My Alienware laptop as well. Both machines are on Windows 7 Pro. I have tried multiple combinations of High/Low settings and none correct the issue.
Seems more like a tech support issue as I have no issues with the cursor. Try over there.