In my opinion they should reimagine set items as the goal of an end game crafting system. I detailed how you can add a 4th artisan to the game - an item artificer - that accomplishes this goal in the thread below.
D4 Feedback - It All Seems to Come Back to Items
I hope that they tell us about their plans for the runeword system and crafting in general. With the emergence of PoE the focus on crafting as part of the ARPG endgame has risen tenfold since D3 was being developed. I’m curious what the D4 devs have learned from that.