D2R - an unexpected error occurred in the application always at the beginning, no chance to get in the Game …the ID`s looks like to be every time different , for example:
46A2197F-9107-4B2E-80CC-4BF72D5AC711
C5AF7A90-BD01-4F44-9305-6928F628CA9C
CBF65DC0-5261-4DD2-A8CB-D7E870682AF6
E890F2E7-B1C5-41D8-9431-AA835340BCC4
Window mode does not work also …
I had a similar problem and it got fixed by rolling back my nvidia driver.
I have the exact same problem and I have not been able to fix it after updating drivers, reinstalling Blizz launcher and game multiple times. Not sure what the issue is because my system is compatible.
Was worth a try but unfortunately its not working 
, the rollback option was greyed out but i reinstalled the newest Nvidia driver but still not working…
Hey there,
I checked the code in our systems and this looks like a graphics-related crash. Please use DDU to uninstall the drivers then reinstall a fresh copy from the Nvidia website. Please also disable any extra software that’s not part of Windows or the game to eliminate them as a possible cause.
Let us know how things go. Cheers!
Hey Kaldraydis,
thank you for your Reply but unfortunately after uninstalling the Nvidia Driver with DDU i got a BOD with inaccessible boot device, so it was time for Reinstall of Win 10 
. Got my new SSD today and already installed Win 10. Will try later to install D2R and then lets see what happen.