Use scroll wheel for both primary and secondary skills

I have use of one hand so I need to be able to use the scroll wheel for both primary and secondary skills. Currently scroll is only set up for secondary skills. Is it too hard to change this ?? Seems it would be easy. This would be of great benefit and game changing for me.

Enter a game, hit esc, hit options, hit configure controls, then program all your mouse buttons to hotkeys, i.e., mouse wheel up and down, m4 and m5 and mouse wheel button. Then go back into the game and allocate the skills you want to the mouse hot keys using the skill speed bar.