So the way i’m playing I got my main attack on left click by default with no keys assigned to it and other skills on quick cast on assigned keys. Every once in a while I end up with a different skill selected.
I disabled the mouse wheel and it still happens. Usually end up with one of my defensive spells on it so I’m guessing it has to do with weapon swapping and quick casting shortly after or at the same time since I recast after using CTA.