Hey guys question,
I’ve never really paid attention, but my significant other asked me a question that I’m not sure of, and can’t get a clear answer from the internet.
Do runes that do that do +health/+mana on kill work when a minion kills said creature? If no then 
If you have a curse on a creature and it dies. Does that count as kill for you too? Therefore, triggering the rune’s effect?
Your character has to be directly responsible for the kill by skills/magic, ranged or melee. Deaths from minions do not count.
An enemy being cursed doesn’t count as damage from you, so that doesn’t work either. Example: Iron Maiden
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You have to damage it yourself and kill it. Traps, minions, your followers don’t count.
Mana per kill is pretty ok if you’re not summoning or using traps.