Thank you for replying MissCheetah. I Hope you are not serious about not knowing about disappearing items since that would mean Devs are not even looking at that issue.
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Charms keep disappearing from inventory and storage - #5 by LostSQ-1865
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Repeatedly losing items in inventory caused by d2s savefile overflow (filecap at 8192bytes)
And there are more reports, those are just 2 threads from the top page from this sub-forum, gathered in <5 min.