Mine was back around 2010 or so. I just started ladder a few hours late and jumped into a cow run game at level 1 to get some quick gold on a paladin. I run around and there’s a 3 open socket great sword on the ground. Then moments later I open a rock and an eth rune pops out. Now that was bliss. The negative def to monsters after I hit 15 made act 2 alot easier for a melee.
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During one ladder reset we were completing hell and first duriel dropped me a vex rune and then mephisto chamber dropped me a lo rune in the same game.
People in the game called me a liar because the chances for these two runes to drop in the same game is abysmal, but its possible 
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Me and girl I was used to play with were doing baalruns on hardcore with new characters at start of season and her father had something urgent and she didnt use tp. She was just standing in middle of throne room waiting for last baal wave to drop. I fought like maniac but it was not enough, Minions of destruction were too strong for me and I had to tacticaly retreat to not die myself 
Well they killed her.
i still recall 2018 ladder reset. the bots were down, people were crying. but everyone else was giving 110% since they now had a chance at succeeding in being no.1. my ladder reset team ran with someone from a competing group, because one of us went to sleep. that dude ran 10 clean baalruns or so with safe tps, and then opened a really dirty unsafe/tp (he was a tele sorc). killed half of my ladder reset group (on hardcore). still hate his guts for that. he did that 100% on purpose, even tauntted us with it. tried to pk him and his guild for a long time.