While it is entirely possible that D2:R may be to blame for the crashes, one thing to keep in mind for ANY software, in order for software to run stable, the hardware platform/drivers/firmware must be stable.
1: Check for and install the latest drivers for your graphics card.
www.nvidia.com/Download/index.aspx?lang=en-us
www.amd.com/en/support
2: Download and install the latest chipset drivers for your system.
For DIY builders:
www.intel.com/content/www/us/en/download-center/home.html
(Intels driver search is horrible, you might have better luck finding them from your motherboard support page)
www.amd.com/en/support
If you have a prebuild or gaming laptop from ASUS, Dell/Alienware, HP or MSI, it’s highly recommended to check their support page for chipset updates first.
www.asus.com/support
www.dell.com/support
www.hp.com/support
support.lenovo.com
www.msi.com/support/download
If not listed, typically www.systembrand.com/support will get you to the right place. If not, try www.systembrand.com and look for ‘drivers’ or ‘support’.
3: Check for and install the latest BIOS firmware for your system board.
- You can check your BIOS firmware version by running ‘dxdiag’, which should list the BIOS version.
- You can also check your BIOS firmware version by entering the BIOS setup pre-Windows boot. (Del, F2 are common to get in pre-boot. If fast-boot is enabled, sometimes you must Shift+Restart, troubleshoot, advanced options, UEFI firmware settings.)
www.asrock.com/support
www.asus.com/support
www.dell.com/support
www.gigabyte.com/Support/Motherboard
www.hp.com/support
support.lenovo.com
www.msi.com/support/download
If not listed, typically www.motherboardbrand.com/support will get you to the right place. If not, try www.motherboardbrand.com and look for ‘drivers’ or ‘support’.
4: If you haven’t blown out the dust from your system in a while (6+ months), DO IT!
5: If you’re running any overclocks (GPU, CPU or RAM), temporarily revert to stock clocks to see if that helps.
Other:
System testing tools:
Test your RAM with Memtest86 - https://www.memtest86.com/ (Have a spare USB drive handy, recommend letting it run the full 4 passes)
Check your storage health with CrystalDiskInfo - https://crystalmark.info/en/download/#CrystalDiskInfo
Check your system temperatures with HWMonitor https://www.cpuid.com/softwares/hwmonitor.html
Stress test your processor with Prime95 https://www.mersenne.org/download/
Stress test your GPU with Furmark https://geeks3d.com/furmark/
*strongly recommend running HWmonitor with Prime95/Furmark to monitor temps.
File system check:
Open an explorer window, right click your system C:\ drive, properties, tools, check drive for errors.
Windows core file integrity checks:
Run a command prompt as administrator, run the following commands:
dism /online /cleanup-image /restorehealth
sfc /scannow
As long as no errors are reported, you’re good. If errors are reported, re-run the commands. If errors are still reported, you need to repair-install Windows.
Repair-install Windows 10: https://www.tomshardware.com/how-to/fix-windows-10-repair-install
Hope this info helps someone solve the issue! 
Please post any other recommendations, or if any of this information helped you!