There is an odd AA type artifact that I’ve noticed when using “open in low resolution mode” that is also present in the new method of changing resolution from the in game system settings. Try it out for yourself. Look at game world text or icons, then mouse click and hold in the game world (doesn’t matter left or right click) and check the text again. You’ll see the text and icons sharpen up while the mouse is held, and go back to fuzzy when you release.
here’s a comparison, done with my phone, because taking screenshots doesn’t show the effect: imgur. com/a/yaEqbGC
If you manually set a display resolution of 1440p for your display prior to launching the game you don’t get this effect, so this is the preferred way to play, at least for me.