Mouse switches from the game pointer to the normal pointer over about 25% of the rightmost portion of my screen and I can’t interact with my 4th and 5th action bars or items in my bags. Was fine before the most recent patch 5.5.2
That sounds like a frustrating issue! I wonder if it could be addon related?
You may wish to check out the Technical Support forums.
restarting the game didn’t fix the problem but restarting the computer did.