I would say it might be a hard thing to do. Because there are a lot of bosses that have slow moving doors that close once you pull the boss or when a scripted event ends, such as the one when Goroth spawns. However if you kill the boss before those doors close, it will glitch out. I know I had something like this in a HFC run I did a few years back where I killed Soc before the doors closed, locking me from progressing to Tyrant. My guess is that the game glitches out as the trigger for reopening the doors fails load as the doors were not closed beforehand.