Interesting. The mouseover macro issue is the biggest cause of this. It’s possible there’s some leftover corrupted cache data in your game’s temporary files as well, since it helped when you disabled things for a while.
I’d test completely resetting your UI and rebuilding everything from scratch. To do this, uninstall any addon managers (Twitch, Overwolf, Wowmatrix, Tukui Client, etc) then reset your UI. If you don’t uninstall addon managers first, it’ll break the UI reset process and we’ll be back at square one.
Now that this is done everything should be fixed. For now, don’t reinstall your addon managers. Instead, you want to manually install the most up to date versions of your addons. Do this one by one and if one breaks it again, reach out to the addon developer to let them know about the problem so they can fix it. After all this is done you should be safe to reinstall any addon managers you may use.