I’ve been experiencing this frequently over the last two days. The microbar and its Hotkeys are nonresponsive. Pressing L to open the quest log or clicking on the quest log icon does not open the log. this is consistent across all buttons on the microbar. Reloading UI seams to help temporarily. It also only seems to show its head after I’ve been in combat.
I do run ElvUI, but my wife does not run addon’s and she is also experiencing the same issue.