Shouldn’t. I’m not sure where SoD’s API is in regards to the bug Blizz introduced in Retail 9.2.5; that’s about the only thing I could see messing with it, but if it was, you’d be casting it on yourself rather than the mouseover target.
I did just notice you’ve got #showtooltipS in your macro rather than #showtooltip but that shouldn’t be affecting the cast.